Daniel Halliday
Nov 26 · Last update 1 mo. ago.
What are the latest breakthroughs in the treatment of HIV/AIDS?
AIDS stands for “acquired immunodeficiency syndrome” and is caused by the human immunodeficiency virus, or HIV. In 2017 there were 36.9 million people living with HIV globally, with the majority of those people living in Sub-Saharan Africa. But approximately 21.7 of those nearly 40 million people are undergoing treatment this year. What advances have lead to this record moment of HIV suppression treatment, and what advances does the future hold in treating this virus before it beings attacking the patients immune system?
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Immunotherapy
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Preventing HIV replication
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Immunotherapy

As the HIV virus works by attacking the immune system, leaving patients more susceptible to other infections and leading to acquired immune deficiency syndrome (AIDS), researchers have been looking into making the immune system stronger to fight these effects. This research has led small French pharmaceutical company InnaVirVax to develop VAC-3S, a drug currently being tested that increases the body’s natural immune response. VAC-3S acts on the patients T lymphocytes (or T-cells), part of the bodies innate immune system, and causes the release of antibodies that attach to the HIV protein "3S", effectively marking the viruses to be destroyed by the T cells. labiotech.eu/interviews/hiv-cure-crouzet-innavirvax

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Preventing HIV replication

ABIVAX, a French biotechnology firm, released results of a clinical trial this year for a potential future treatment and/or functional cure for HIV called ABX464. The medication works by interfering with the virus’ mode of replication and targets instances of the virus that are ‘hiding’ in the patients cells. Most treatments do not address the presence of this hidden HIV reservoir, but as ABX464 interferes with HIV’ life cycle patients were reported to have a 52% decrease in viral DNA in their blood after just 28 days of a daily 150mg dose.

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