D H
Nov 24 · Last update 8 days ago.

Why has the Delta wave ended in Japan?

The US and Europe are currently experiencing a steady increase in the number of COVID-19 infections in line with the winter cold and flu season, however things are quite different in Japan. Japan had a massive increase in COVID cases of near crisis proportions following the Olympics in the summer of 2021, but following this the country has seen new COVID infections plummet quite dramatically. Japan has caught up on an initially slow vaccine roll out, but this cannot fully explain this remarkable fall in cases, as neighbouring South Korea have higher vaccination rates but have not noted the same level of decline in COVID-19. The virus is similarly holding on in Spain, Portugal, Canada, and Singapore despite higher levels of vaccination. So what could be different about Japan? What evidence do we have for this? Why has the delta wave seemingly ended in Japan when its going the other way pretty much everywhere else?
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Human genetics in Japan
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Driven to self extinction
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Human genetics in Japan

Debate still stands over the difference the nsp14 variation causes in virus structure, but another possible genetic variation of note is in the Japanese people themselves. As a racially homogenous country that was historically closed off to the world, Japan is genetically somewhat more homogenous than the rest of the world. According to research more people in Asia have a defence enzyme called APOBEC3A that attacks RNA viruses, and COVID-19 is indeed caused by an RNA virus SARS-CoV-2, and this may be even more prevalent in countries of high homogeneity like Japan. Research to discover how APOBEC3A affects nsp14 is now being carried out at the University of Niigata. But COVID-19 seems to have suddenly declined in Japan in a similar way to the abrupt end to SARS in 2003, which is leading some to speculate that this could have been due to this higher prevalence of APOBEC3A that gives rise to higher RNA virus immunity.

world-today-news.com/a-scientist-announced-that-the-delta-variant-in-japan-has-self-destructed

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D H
Nov 27
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Driven to self extinction

Evidence is coming to light that in Japan the delta variant of SARS-CoV-2 that causes COVID-19 may have mutated further in a way that has drive the virus to near extinction there. The Delta variant in Japan has been found to have accumulated too many mutations, where the virus’s error-correcting gene nsp14 (non-structural protein 14), a protein that checks for inaccuracies in genetic replication - essentially genetic error correcting, an error here could make the virus not reproduce properly and lead to the proliferation of genetically useless viruses. The majority of the nsp14 specimens in Japan were found to have a A394V mutation, which would make the virus replicate inaccurately into unviable forms, which is consistent with the huge drop in COVID numbers in Japan and reveals another possible route for investigation in the fight against SARS-CoV-2.

news-tunisia.tunisienumerique.com/new-research-suggests-delta-strain-drove-itself-to-extinction-in-japan japantimes.co.jp/news/2021/11/18/national/delta-variant-self-destruction-theory ncbi.nlm.nih.gov/pmc/articles/PMC4934755 rt.com/news/540895-japan-delta-covid-extinction

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D H
Nov 24
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